Dimethyl Sulfoxide
Sigma Aldrich Methyl phenyl sulfoxide
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Phenyl vinyl sulfoxide
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Fine Chemicals Biosciences DIMETHYL SULFOXIDE 5X5ML
NC3592569 DIMETHYL SULFOXIDE 5X5ML
PROTIDE PHARMACEUTICAL STEMSOL 99.9% DMSO USP VIAL GLASS 50ML
STEMSOL 99.9% DMSO USP VIAL GLASS 50ML
VWR INTERNATIONAL LLC Dimethyl sulfoxide | MW: 78.14 g/mol | 67-68-5 | MFCD00002089 | 5 x 10mL
Dimethyl sulfoxide | Purity: ≥99.9% | Ultra Pure Grade | MW: 78.14 g/mol | 67-68-5 | MFCD00002089 | 5 x 10mL
Medchemexpress LLC Rsl3 10Mm In 1Ml Dmso Reconsti | HY-100218A-10MM-1ML
Rsl3 10Mm In 1Ml Dmso Reconsti
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 1L
Molecular Formula: (CH3)2SO, Molecular Weight: 78.13, Beilstein Registry Number: 506008, Assay: ≥99.5% (GC)
Apexbio Technology LLC WZ4002 1213269-23-8 10mM (in 1mL DMSO)
WZ4002 (CAS 1213269-23-8) is an irreversible EGFR tyrosine kinase inhibitor that selectively targets mutant epidermal growth factor receptor (EGFR) variants It potently inhibits autophosphorylation of EGFR mutants including T790M L858R/T790M delE746 A750/T790M L858R and delE746 A750 at low nanomolar Ki values Compared to wild-type EGFR mutant EGFR demonstrates greater sensitivity to WZ4002 at lower concentrations limiting off-target toxicity in normal tissues WZ4002 serves as a research tool for studying EGFR-driven tumorigenesis and therapeutic resistance in oncology models
Apexbio Technology LLC AS 602801 848344-36-5 10mM (in 1mL DMSO)
AS 602801 (CAS 848344-36-5) is a selective small-molecule inhibitor targeting c-Jun N-terminal kinase (JNK) a kinase implicated in immune and apoptotic signaling pathways Preclinical studies indicate that AS 602801 suppresses T-cell proliferation and promotes apoptosis altering gene expression in RRMS-derived CD4 and CD8 T-cells and innate receptor expression in RRMS-associated CD11b cells Animal models show beneficial effects in autoimmune disorders and neuronal apoptosis scenarios Thus AS 602801 is investigated primarily for therapeutic potential in multiple sclerosis and fibrotic conditions
Selleck Chemical LLC JNK-IN-8 - 10mM 1mL in DMSO99.16 purity
JNK-IN-8 - 10mM 1mL in DMSO99.16 purity
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide PCR Reagent | 67-68-5 | MFCD00002089 | 5vl
Dimethyl sulfoxide PCR Reagent | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 5vl
Apexbio Technology LLC Tirapazamine(Synonyms: SR-4233, WIN 59075, Tirazone, TPZ, 3-Amino-1,2,4-benzotriazine 1,4-dioxide), 10mM (in 1mL DMSO), CAS: 27314-97-2.
Tirapazamine (CAS 27314-97-2) also known as SR259075 Win59075 or SR4233 is an investigational anticancer agent selectively activated under hypoxic conditions characteristic of solid tumors The compound is bioreduced in hypoxic tumor microenvironments to cytotoxic free radicals leading to cellular damage Tirapazamine downregulates hypoxia-inducible factor-1 (HIF-1 ) thereby influencing pathways associated with tumor adaptive mechanisms to hypoxia Combined treatment with tirapazamine and topoisomerase I inhibitors (such as SN-38 the active metabolite of irinotecan) enhances apoptosis via mitochondria-mediated caspase activation and weakened DNA repair signaling Preclinical investigations including hepatocellular carcinoma xenografts confirm this enhanced tumor suppression Clinical trials evaluating tirapazamine s anticancer efficacy are ongoing
Apexbio Technology LLC (+)-Bicuculline 485-49-4 10mM (in 1mL DMSO)
( )-Bicuculline is a competitive antagonist of gamma-aminobutyric acid type A (GABA A) receptors frequently employed as a pharmacological tool to elucidate the functional roles of inhibitory neurotransmission mediated by GABA A By antagonizing GABA binding this compound prevents chloride ion influx leading to reductions in neuronal inhibitory postsynaptic potentials (IPSPs) Additionally ( )-Bicuculline blocks small conductance calcium-activated potassium (SK) channels affecting neuronal excitability and firing patterns It is commonly utilized in electrophysiological studies such as patch-clamp or extracellular recordings to investigate synaptic transmission neuroplasticity mechanisms and epileptic activity models ( )-Bicuculline inhibits GABA A receptors with an IC 50 typically reported in the low micromolar range (approximately 2 5 M)