Dimethyl Sulfoxide
Sigma Aldrich Methyl phenyl sulfoxide
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Sigma Aldrich Fine Chemicals Biosciences DIMETHYL SULFOXIDE 5X5ML
NC3592569 DIMETHYL SULFOXIDE 5X5ML
VWR INTERNATIONAL LLC Dimethyl sulfoxide | MW: 78.14 g/mol | 67-68-5 | MFCD00002089 | 5 x 10mL
Dimethyl sulfoxide | Purity: ≥99.9% | Ultra Pure Grade | MW: 78.14 g/mol | 67-68-5 | MFCD00002089 | 5 x 10mL
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL
Apexbio Technology LLC Brassinolide 72962-43-7 10mM (in 1mL DMSO)
Brassinolide (CAS 72962-43-7) is a naturally occurring steroidal plant growth regulator It influences various physiological processes in plants including stem elongation leaf differentiation flower formation and fruit development In vitro studies indicated that brassinolide induces apoptosis in human prostate cancer PC-3 cells characterized by increased caspase-3 activity and decreased Bcl-2 protein expression In animal models brassinolide reduced blood glucose levels in diabetic rats demonstrating non-dose-dependent hypoglycemic effects without observed toxicity Brassinolide is valuable in research related to cancer cell apoptosis and glucose metabolism regulation
Apexbio Technology LLC Marimastat 154039-60-8 10mM (in 1mL DMSO)
Marimastat (CAS 154039-60-8) also known as BB-2516 is an orally bioavailable inhibitor of matrix metalloproteases (MMPs) Structurally it contains a collagen-mimicking hydroxamate moiety that facilitates covalent binding to the zinc atom at MMP active sites Marimastat exhibits broad-spectrum inhibitory activity against MMP-1 MMP-2 MMP-7 MMP-9 and MMP-14 with IC50 values of 5 nM 6 nM 13 nM 3 nM and 9 nM respectively In animal models of metastatic cancers Marimastat reduces tumor dissemination and progression Clinically Marimastat is investigated for potential therapeutic effects against metastatic and non-metastatic solid tumors such as pancreatic and gastric cancers
Apexbio Technology LLC ML216 1430213-30-1 10mM (in 1mL DMSO)
ML216 (CAS 1430213-30-1) is a small molecule inhibitor targeting Bloom (BLM) helicase a DNA unwinding enzyme essential for homologous recombination-mediated DNA repair ML216 inhibits DNA unwinding activity of full-length BLM (IC50 3 0 M) and a truncated form BLM636-1298 (IC50 0 97 M) displaying sub-micromolar selectivity relative to other helicases such as RECQ1 RECQL5 and bacterial UvrD In cellular assays ML216 selectively suppresses proliferation in BLM-containing fibroblasts increasing sister chromatid exchange frequency consistent with BLM functional deficiency By inhibiting BLM helicase ML216 may sensitize tumor cells to conventional DNA-damaging therapeutics indicating potential application in cancer research and therapy development
Medchemexpress LLC IRG1 IN 1 10 MM 1 ML IN DMSO
IRG1-IN-1 10 mM 1 mL in DMSO ready for reconstitution
Apexbio Technology LLC Celastrol 34157-83-0 10mM (in 1mL DMSO)
Celastrol (CAS 34157-83-0) is a triterpene compound isolated from the Chinese medicinal herb Thunder of God Vine It functions as a proteasome inhibitor targeting the proteolytic activities within the 20S and 26S proteasome complexes leading to intracellular accumulation of ubiquitinated substrates including I B- Bax and p27 thereby inducing apoptosis in cancer cell lines such as human prostate cancer (PC-3 and LNCaP) Celastrol also inhibits NF- B signaling decreasing LPS-induced production of inflammatory cytokines (TNF- and IL-1 ) in human PBMCs and augmenting TNF-mediated apoptosis in KBM-5 cells Its anti-inflammatory and pro-apoptotic properties make celastrol relevant in cancer and inflammation research
Apexbio Technology LLC Pyridostatin | 1085412-37-8 | 596.6 g/mol | 10MM IN 1ML DMSO
Pyridostatin | 1085412-37-8 | 596.6 g/mol | 10MM IN 1ML DMSO